Claudia Giachino

Current position:

• 2021-present  Full Professor of Technical Sciences in Laboratory Medicine, Department of Clinical and Biological Sciences, University of Turin, Italy.
• 2021-present  Coordinator of the Translational Research Centre for Innovative Medicine, University of Turin, Italy.

Previous working positions:

• 1998-2003 Head of the Experimental Immunogenetics laboratory, IRCCS Maugeri Foundation, Pavia, Italy.
• 1999-2005 Assistant Professor of Molecular Biology, University of Turin, Italy.
• 2006-2019 Associate Professor of Medical Genetics, University of Turin, Italy.
• 2019-2021 Associate Professor of Technical Sciences in Laboratory Medicine, University of Turin, Italy.

Thanks to a mixed approach between basic and translational science, my group deepens the knowledge of molecular genetics and innovative medicine, ranging from circulating tumor cells to stem cell senescence, and from regenerative medicine to nanomedicine. Currently we actively collaborate with various groups within and outside our Department, in order to develop i) innovative cardiac patches for heart failure prevention, ii) molecular approaches for evaluating the circulating tumor cells in liquid biopsies, iii) nanotechnological approaches for the treatment of monogenic and complex genetic diseases. We are active in scientific dissemination, patenting, and technology transfer activities.

• 2018-2021 EUROPEAN UNION – M-ERANET grant. INCIPIT: INtegrated Conductive and biomimetic polymeric Interfaces able to serve as micro-nanostructured Patches for myocardIal regeneration. Partner
• 2019-2021 PROGETTI DI ATENEO – COMPAGNIA DI SAN PAOLO. Bando ex-post 2018. Key reactive molecules as exhaled breath biomarkers for disease diagnostics and monitoring/Biomedical applications of innovative micronanoparticles. PI
• 2021    CSP/LIFTT Proof-of-concept grant. Technological transfer study IMPAVID- A polymeric scaffold for cardiac regeneration and protection from reperfusion injury. PI
• 2021-2024 ITALIAN MINISTRY OF HEALTH – Bando Ricerca Finalizzata 2019. Association of paid work, child and elders care with the risk of cardiovascular diseases. Partner
• 2023-2024 CSP/LIFTT PoC Transition. Technological transfer study IMPAVID – industrial prototype. PI
• 2023-2026 EUROPEAN UNION – EURAMET grant. GenomeMET: Metrology for genomic profiling to support early cancer detection and precision medicine. Partner

1. Apelin-13 Increases Functional Connexin-43 through Autophagy Inhibition via AKT/mTOR Pathway in the Non-Myocytic Cell Population of the Heart

Vitale, E., Rosso, R., Lo Iacono, M., [...] Giachino, C., Rastaldo, R.

International Journal of Molecular Sciences, 2022, 23(21), 13073 co-last

2. Therapeutic acellular scaffolds for limiting left ventricular remodelling-current status and future directions

Perveen, S., Rossin, D., Vitale, E., [...] Rastaldo, R., Giachino, C.

International Journal of Molecular Sciences, 2021, 22(23), 13054

3. Nanoengineering in cardiac regeneration: Looking back and going forward

Cristallini, C., Vitale, E., Giachino, C., Rastaldo, R.

Nanomaterials, 2020, 10(8), pp. 1–28, 1587 co-last

4. Dual Role of Autophagy in Regulation of Mesenchymal Stem Cell Senescence

Rastaldo, R., Vitale, E., Giachino, C.

Frontiers in Cell and Developmental Biology, 2020, 8, 276

5. Risk assessment and risk minimization in nanomedicine: A need for predictive, alternative, and 3Rs strategies

Accomasso, L., Cristallini, C., Giachino, C.

Frontiers in Pharmacology, 2018, 9(MAR), 228

6. Senescence in human mesenchymal stem cells: Functional changes and implications in stem cell-based therapy

Turinetto, V., Vitale, E., Giachino, C.

International Journal of Molecular Sciences, 2016, 17(7), 1164

7. Survey and summary multiple facets of histone variant H2AX: A DNA double-strand-break marker with several biological functions

Turinetto, V., Giachino, C.

Nucleic Acids Research, 2015, 43(5), pp. 2489–2498

8. Normal T lymphocytes can express two different T cell receptor β chains: Implications for the mechanism of allelic exclusion

Padovan, E., Giachino, C., Cella, M. [...] Acuto, O., Lanzavecchia, A.

Journal of Experimental Medicine, 1995, 181(4), pp. 1587–1591

9. κ+γ+ Dual receptor B cells are present in the human peripheral repertoire

Giachino, C., Padovan, E., Lanzavecchia, A.

Journal of Experimental Medicine, 1995, 181(3), pp. 1245–1250

10. Selection by two powerful antigens may account for the presence of the major population of human peripheral γ/δ T cells

De Libero, G., Casorati, G., Giachino, C., [...] Matzinger, P., Lanzavecchia, A.

Journal of Experimental Medicine, 1991, 173(6), pp. 1311–1322